Sofpironium (Sofdra)

What is Sofdra?

Sofdra is a topical prescription treatment for primary axillary hyperhidrosis, meaning excessive underarm sweating. It offers a non-oral treatment option for patients who want a more localized approach.

That can make it attractive for patients who want to avoid the dry mouth and other whole-body side effects that sometimes come with oral anticholinergic medications.

How does Sofdra work?

Sofdra works through an anticholinergic effect that decreases signaling to sweat glands. Because it is applied to the underarm rather than taken by mouth, it is designed to work more locally.

It is best thought of as a medication for underarm sweating specifically rather than a treatment for all forms of hyperhidrosis.

What are possible side effects of Sofdra?

Possible side effects can include:

• Application-site irritation

• Dryness

• Blurred vision if the medication is transferred to the eyes

• Dry mouth or other anticholinergic-type effects in some patients

Patients should wash their hands after application and avoid getting the medication in the eyes. People with certain eye, urinary, or anticholinergic-sensitive conditions may need a more individualized discussion before using it.

How is Sofdra used?

Sofdra is applied to the underarm area as directed by your provider. It is intended for axillary hyperhidrosis..

The gel is flammable during and immediately after application, so patients should avoid fire, flame, and smoking until it has dried. Using it on clean, dry underarm skin and following application directions carefully can help reduce irritation and transfer to other body areas.