Delgocitinib (Anzupgo)

What is delgocitinib?

Delgocitinib (Anzupgo) is a nonsteroidal topical medication used for chronic hand eczema. It is an important newer option for patients whose hand eczema remains difficult to control or for whom ongoing topical steroid use may not be ideal.

Because hand eczema can be persistent, painful, and disruptive to daily life, a steroid-free option can be especially useful in the right situation. It may be particularly relevant for patients whose disease interferes with work, childcare, hand washing, or other repeated daily exposures.

How does delgocitinib work?

Delgocitinib is a topical JAK inhibitor. It works by reducing inflammatory signaling in the skin, which can help calm redness, itching, irritation, and the cycle of inflammation that drives chronic hand eczema.

That makes it different from moisturizers and barrier repair alone, while still being a nonsteroidal option.

What are possible side effects of delgocitinib?

Possible side effects can include:

  • Mild irritation where the cream is applied

  • Burning or stinging

  • Redness

  • Itching

  • Application-site discomfort

As with many topical medications, patients should contact their dermatologist if irritation is significant or if the medication does not seem to be helping enough.

How is delgocitinib used?

Delgocitinib is applied topically to affected hand areas as directed by your dermatologist. It is generally considered when chronic hand eczema has not responded well enough to more basic topical treatment approaches.

Because chronic hand eczema is often tied to irritants and repeated exposure, treatment usually works best when combined with trigger reduction, hand protection, and moisturization.

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