Isotretinoin (Accutane)

What is isotretinoin?

Isotretinoin (Accutane) is a retinoid, derived from vitamin A, used primarily for the treatment of severe acne. It is a potent medication, and many people who complete a treatment course experience long-term remission from acne. Because of its potential side effects, it is generally reserved for patients with more significant acne who have not responded well enough to other treatments.

What are possible side effects of isotretinoin?

Isotretinoin has a range of side effects that need to be carefully considered. These fall into several major categories:

  • Skin dryness and sun sensitivity: gentle skincare, sun protection, and avoiding procedures that impair healing are important.

  • Lab abnormalities: these may include liver enzyme or triglyceride changes.

  • Risk of birth defects: patients who can become pregnant must follow the current iPLEDGE pregnancy-prevention requirements. Your dermatologist will review the current program steps that apply to your category before and during treatment.

  • Rare risk of mood changes: most people do well, but mood symptoms should be discussed promptly if they arise.

Side effects generally improve within a month after the medication is stopped.

How is isotretinoin used?

Opting for isotretinoin treatment is a significant decision that requires strict adherence to the treatment protocol. This includes monthly appointments, regular lab tests, and open communication with your healthcare provider.

For more detailed guidance, consult the isotretinoin instruction sheet and isotretinoin FAQ sheet available under patient resources.

THIS CONTENT IS INTENDED SOLELY FOR EDUCATIONAL PURPOSES AND MAY NOT BE COMPREHENSIVE. IT DOES NOT CONSTITUTE MEDICAL ADVICE. PLEASE REFER TO OUR TERMS OF USE FOR FURTHER DETAILS. ALWAYS CONSULT WITH YOUR HEALTHCARE PROVIDER BEFORE MAKING ANY MEDICAL DECISIONS.