Tapinarof (VTAMA)

What is Tapinarof?

Tapinarof (VTAMA) is a nonsteroidal topical medication used in dermatology for inflammatory skin conditions, especially plaque psoriasis and atopic dermatitis (eczema). It is often appealing to patients who want a steroid-free option that can be used on many body sites, including areas where long-term topical steroid use may be less desirable.

How does tapinarof work?

Tapinarof works through the aryl hydrocarbon receptor, often shortened to AhR. This helps regulate inflammation in the skin and also supports skin-barrier function. Because of this dual effect, tapinarof can be useful in both psoriasis and eczema.

What are possible side effects of Tapinarof?

Tapinarof is often well tolerated, but possible side effects can include:

These side effects are often manageable, but patients should let their dermatologist know if irritation becomes significant.

How is Tapinarof used?

Tapinarof is a cream that is typically applied once daily to affected areas as directed. A thin layer is usually all that is needed. Avoid contact with the eyes, mouth, and other mucous membranes.

One advantage of tapinarof is that it is steroid-free and can be used in a way that is often more flexible than traditional topical steroids.

THIS CONTENT IS INTENDED SOLELY FOR EDUCATIONAL PURPOSES AND MAY NOT BE COMPREHENSIVE. IT DOES NOT CONSTITUTE MEDICAL ADVICE. PLEASE REFER TO OUR TERMS OF USE FOR FURTHER DETAILS. ALWAYS CONSULT WITH YOUR HEALTHCARE PROVIDER BEFORE MAKING ANY MEDICAL DECISIONS.