Topical PDE4 Inhibitors

What are topical PDE4 inhibitors?

Topical PDE4 inhibitors are nonsteroidal anti-inflammatory medications used in dermatology to treat certain inflammatory skin conditions. PDE4 stands for phosphodiesterase-4, an enzyme involved in inflammatory signaling in the skin. By blocking this pathway, these medications can help reduce redness, itch, and inflammation without the use of topical steroids.

This medication group has expanded over time and now includes more than one treatment option.

Which topical PDE4 inhibitors are used in dermatology?

Topical PDE4 inhibitors used in dermatology include:

• Crisaborole (Eucrisa): commonly used for atopic dermatitis

• Roflumilast (Zoryve): used in dermatology for conditions such as plaque psoriasis, seborrheic dermatitis, and atopic dermatitis

• Difamilast (Adquey): a newer nonsteroidal topical option used for atopic dermatitis

These medications help give patients more choices, especially when treating chronic or sensitive-area disease.

What are possible side effects of topical PDE4 inhibitors?

Topical PDE4 inhibitors are often well tolerated, but side effects can include:

• Burning or stinging when first applied

• Mild redness or irritation

• Itching

• Discomfort in the treated area

Side effects vary somewhat by product, but many patients tolerate these medications well once their skin adjusts.

How are topical PDE4 inhibitors used?

These medications are applied directly to affected skin as directed by your dermatologist. The specific frequency and instructions depend on the product and the condition being treated.

Because they are steroid-free, topical PDE4 inhibitors are often considered when patients want long-term nonsteroidal options or when treatment is needed on more delicate skin sites.